Article Text

other Versions

PDF
A review of the neuroimaging findings in human prion disease
  1. Macfarlane RG (r.macfarlane{at}prion.ucl.ac.uk)
  1. MRC Prion Unit, Institute of Neurology, Queen Square, London, United Kingdom
    1. Wroe SJ
    1. MRC Prion Unit, Institute of Neurology, Queen Square, London, United Kingdom
      1. Collinge J
      1. MRC Prion Unit, Institute of Neurology, Queen Square, London, United Kingdom
        1. Yousry TA
        1. Lysholm Department of Neuroradiology, National Hospital of Neurology and Neurosurgery, Queen Square, United Kingdom
          1. Jager R
          1. Lysholm Department of Neuroradiology, National Hospital of Neurology and Neurosurgery, Queen Square, United Kingdom

            Abstract

            Imaging occupies an important role in the investigation of dementia and neurodegenerative disease. The role of imaging in prion disease used to be one of exclusion of other conditions. Over the last decade, the non-invasive nature of MRI, the improved range of MR sequences and availability of clinical and neuropathological correlation, have lead to a more prominent position of MRI and its inclusion in the diagnostic criteria for vCJD. As experience of imaging in human prion disease increases, patterns of change related to strain and genotype may improve the diagnostic potential of imaging in the future, may reduce the need for more invasive testing and prove useful in future therapeutic trials. This paper reviews the current knowledge of imaging appearances in human prion disease.

            • creutzfeldt-jakob disease
            • diffusion weighted imaging (DWI)
            • fluid attenuated inversion recovery Imaging (FLAIR)
            • magnetic resonance imaging (MRI)
            • prion

            Statistics from Altmetric.com

            Request permissions

            If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.