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Paraneoplastic cerebellar degeneration and anti-Yo antibodies in a man with prostatic adenocarcinoma
  1. J Matschke (matschke{at}uke.uni-hamburg.de)
  1. Institute of Neuropathology, Germany
    1. A Kromminga
    1. Institute for Immunology, Clinical Pathology, Molecular Medicine, Germany
      1. A Erbersdobler
      1. Institute of Pathology, Germany
        1. K Lamszus
        1. Institute of Neuropathology, Germany
          1. S Anders
          1. Institute of Pathology, Germany
            1. E Köfüncü
            1. Neurological Clinic, Germany

              Abstract

              Paraneoplastic cerebellar degeneration (PCD) is a heterogeneous group of disorders, characterized by the subacute onset of a cerebellar syndrome in patients with cancer . Although PCD may occur in patients with a variety of cancers with or without auto-antibodies, it most commonly is associated with ovarian or breast tumors in women seropositive for anti-Yo antibodies. The anti-Yo antibodies bind to protein antigens of 34 and 62 kD, respectively, found exclusively in the cytoplasm of Purkinje cells. Morphological studies have revealed loss of Purkinje cells accompanied by relatively few or absent inflammatory changes 1. We present a case of a man with a subacute cerebellar syndrome in whom further diagnostic workup disclosed prostatic adenocarcinoma (PA) and anti-Yo antibodies. Furthermore, the PA showed expression of Yo antigen. Therefore, this case represents simultaneously the first case of PCD associated with PA as well as the fifth case of anti-Yo positive PCD in a male patient.

              • anti-yo antibodies
              • paraneoplastic cerebellar degeneration
              • paraneoplastic neurological syndrome
              • prostatic adenocarcinoma

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