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PINK1, a gene product of PARK6, accumulates in α-synucleinopathy brains
  1. Tetsuro Murakami (neuron{at}cc.okayama-u.ac.jp)
  1. Department of Neurology, Okayama University Medical School, Japan
    1. Yasuhiro Moriwaki (moriwaki-ys{at}kyoritsu-ph.ac.jp)
    1. Kyoritsu University of Pharmacy, Department of Clinical Pharmacy, Division of Pharmacology, Japan
      1. Takeshi Kawarabayashi (tkawara{at}cc.okayama-u.ac.jp)
      1. Department of Neurology, Okayama University Medical School, Japan
        1. Makiko Nagai (nagaima{at}cc.okayama-u.ac.jp)
        1. Department of Neurology, Okayama University Medical School, Japan
          1. Yasuyuki Ohta
          1. Department of Neurology, Okayama University Medical School
            1. Kentaro Deguchi
            1. Department of Neurology, Okayama University Medical School, Japan
              1. Tomoko Kurata
              1. Department of Neurology, Okayama University Medical School, Japan
                1. Yasushi Takehisa
                1. Department of Neurology, Okayama University Medical School, Japan
                  1. Etsuro Matsubara
                  1. Department of Alzheimerfs disease Research, National Institute of Longevity Sciences, Japan
                    1. Masaki Ikeda
                    1. Department of Neurology, Gunma University Graduate School of Medicine, Japan
                      1. Yasuo Harigaya
                      1. Department of Neurology, Maebashi Red Cross Hospital, Japan
                        1. Mikio Shoji
                        1. Department of Neurological Science, Hirosaki University School of Medicine, Japan
                          1. Ryosuke Takahashi
                          1. Department of Neurology, Kyoto University Graduate School of Medicine, Japan
                            1. Koji Abe
                            1. Department of Neurology, Okayama University Medical School, Japan

                              Abstract

                              α-synucleinopathy is an entity of neurodegenerative diseases that involve the accumulation of α-synuclein in the brain, such as Parkinsonfs disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). PINK1 (PTEN-induced kinase 1) is a novel gene recently identified as a causative gene of autosomal recessive early-onset parkinsonism (PARK6). In the present study, we examined the localization of PINK1 in α-synucleinopathy brains and found that PINK1 in glial cytoplasmic inclusions (GCIs) in MSA, as well as Lewy bodies (LBs) in PD and DLB. These findings imply that PINK1 may be involved in the formation of LBs and GCIs, suggesting that PINK1 is one of the major pathological proteins in α-synucleinopathy.

                              • Lewy body
                              • PINK1
                              • Parkinson's disease
                              • alpha-synucleinopathy
                              • multiple system atrophy

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