Background: Identifying quantitative gait markers of preclinical dementia may lead to new insights into early disease stages, improve diagnostic assessments, and identify new preventive strategies.
Objective: To examine relationship of quantitative gait parameters with decline on specific cognitive domains as well as risk of developing dementia in older adults.
Methods: We conducted a prospective cohort study nested within a community based aging study. Of the 427 subjects aged 70 and older with quantitative gait assessments, 399 were dementia-free at baseline.
Results: Over 5 years follow-up (median 2 years), 33 subjects developed dementia. Factor analysis was used to reduce eight baseline quantitative gait parameters to three independent factors representing pace, rhythm, and variability. In linear models, a one-point increase on the rhythm factor was associated with further memory decline (by 107%), whereas the pace factor was associated with decline on executive function measured by the digit symbol substitution (by 29%) and letter fluency tests (by 92%). In Cox models adjusted for age, sex, and education, a one-point increase on baseline rhythm (hazard ratio [HR] 1.48; 95% CI 1.03-2.14) and variability factor scores (HR 1.37; 95% CI 1.05-1.78) were associated with increased risk of dementia. The pace factor predicted risk of developing vascular dementia (HR 1.60; 95% CI 1.06-2.41).
Conclusion: Our findings indicate that quantitative gait measures predict future risk of cognitive decline and dementia in initially nondemented older adults.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.