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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp.2006.108076

Profile of cognitive impairment in dementia associated with Parkinson’s disease compared to Alzheimer disease

  1. Kolbjorn Bronnick (bronnick{at}gmail.com)
  1. Stavanger University Hospital, Norway
    1. Murat Emre (muratemre{at}superonline.com)
    1. Istanbul University, Turkey
      1. Roger Lane (roger.lane{at}novartis.com)
      1. Novartis Pharmaceuticals, United States
        1. Sibel Tekin (sibel.tekin{at}novartis.com)
        1. Novartis Pharmaceuticals, United States
          1. Dag Aarsland (daa{at}sir.no)
          1. Stavanger University Hospital, Norway
            • Published Online First 7 February 2007

            Abstract

            Objective: To compare the profile of cognitive impairment in Alzheimer’s disease (AD) to dementia associated with Parkinson’s disease (PDD).

            Methods: Neuropsychological assessment was performed in 488 patients with PDD and 488 patients with AD using MMSE and ADAS-cog. Logistic regression analysis was used to investigate whether the diagnosis could be accurately predicted from the cognitive profile. Additionally, the cognitive profiles were compared to a normative group using standardized effect-sizes (Cohen’s d).

            Results: Diagnosis could be predicted from the cognitive profile with an overall accuracy of 74.7%. Poor performance of the AD patients on the orientation test in ADAS-cog best discriminated between the groups, followed by poor performance of the PDD patients on the attentional task in MMSE. Both groups showed memory-impairment, AD patients performing worse than the PDD patients.

            Conclusion: The cognitive profile in PDD differs significantly from that in AD. Performance on tests of orientation and attention best differentiates the groups.

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