Article Text

other Versions

PDF
Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus. Results of a pilot study
  1. Maria M Matarin (matarinm{at}grc.nia.nih.gov)
  1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, Spain
    1. Roser Pueyo (rpueyo{at}ub.edu)
    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, Spain
      1. Maria A Poca (26382app{at}comb.es)
      1. Department of Neurosurgery , Vall d’Hebron University Hospital, Autonomous University of Barcelona, Spain
        1. Carles Falcón (cfalcon{at}clinic.ub.es)
        1. August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain
          1. Maria Mataro (mmataro{at}teleline.es)
          1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, Spain
            1. Nuria Bargallo (bargallo{at}clinic.ub.es)
            1. Department of Neuroradiology, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain, Spain
              1. Juan Sahuquillo (sahuquillo{at}neurotrauma.net)
              1. Department of Neurosurgery , Vall d’Hebron University Hospital, Autonomous University of Barcelona,, Spain
                1. Carme Junque (cjunque{at}ub.edu)
                1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; IDIBAPS, Spain

                  Abstract

                  Background: Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment.

                  Objectives: The present study focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment and its clinical and cognitive correlation.

                  Methods: 1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in twelve adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myo- inositol (MI) and creatine (Cr) values.

                  Results: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.

                  Conclusion: MR spectroscopy could be a marker of neuronal dysfunction in NPH.

                  • cognitive functions
                  • neurosurgical treatment
                  • normal pressure hydrocephalus
                  • proton magnetic resonance spectroscopy
                  • reversible dementia

                  Statistics from Altmetric.com

                  Request permissions

                  If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.