Background: Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment.
Objectives: The present study focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment and its clinical and cognitive correlation.
Methods: 1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in twelve adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myo- inositol (MI) and creatine (Cr) values.
Results: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.
Conclusion: MR spectroscopy could be a marker of neuronal dysfunction in NPH.
- cognitive functions
- neurosurgical treatment
- normal pressure hydrocephalus
- proton magnetic resonance spectroscopy
- reversible dementia