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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp.2006.088450

Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus. Results of a pilot study

  1. Maria M Matarin (matarinm{at}grc.nia.nih.gov)
  1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, Spain
    1. Roser Pueyo (rpueyo{at}ub.edu)
    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, Spain
      1. Maria A Poca (26382app{at}comb.es)
      1. Department of Neurosurgery , Vall d’Hebron University Hospital, Autonomous University of Barcelona, Spain
        1. Carles Falcón (cfalcon{at}clinic.ub.es)
        1. August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain
          1. Maria Mataro (mmataro{at}teleline.es)
          1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain, Spain
            1. Nuria Bargallo (bargallo{at}clinic.ub.es)
            1. Department of Neuroradiology, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain, Spain
              1. Juan Sahuquillo (sahuquillo{at}neurotrauma.net)
              1. Department of Neurosurgery , Vall d’Hebron University Hospital, Autonomous University of Barcelona,, Spain
                1. Carme Junque (cjunque{at}ub.edu)
                1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain; IDIBAPS, Spain
                  • Published Online First 13 February 2007

                  Abstract

                  Background: Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment.

                  Objectives: The present study focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment and its clinical and cognitive correlation.

                  Methods: 1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in twelve adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myo- inositol (MI) and creatine (Cr) values.

                  Results: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.

                  Conclusion: MR spectroscopy could be a marker of neuronal dysfunction in NPH.

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