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Absence of paraneoplastic antineuronal antibodies in sera of 145 patients with motor neuron disease
  1. Oliver Stich (stich{at}nz.ukl.uni-freiburg.de)
  1. Neurologische Klinik und Poliklinik der Albert-Ludwigs-Universitaet Freiburg, Germany
    1. Barbara Kleer (fishies{at}web.de)
    1. Neurologische Klinik und Poliklinik der Albert-Ludwigs-Universitaet Freiburg, Germany
      1. Sebastian Rauer (sebastian.rauer{at}uniklinik-freiburg.de)
      1. Neurologische Klinik und Poliklinik der Albert-Ludwigs-Universitaet Freiburg, Germany

        Abstract

        Background: Well characterized antineuronal antibodies (ANAbs) have been shown to be high specific markers for neurological syndromes with a paraneoplastic etiology. Previous reports indicate that pure motor neuron disease (MND) is rarely of paraneoplastic origin.

        Objective: To screen systematically for the prevalence of well characterized paraneoplastic ANAbs in a large collective of patients with pure MND.

        Methods: In a cohort of 145 patients with MND, the frequency of ANAbs was estimated by ELISA employing recombinant antigens (HuD, Yo, Ri, CV2/CRMP5, Ma2, amphiphysin).

        Results: None of the sera revealed high anti-neuronal antigen reactivity. Only in five sera could very low reactivity be detected, in all probability representing background activity.

        Conclusion: According to these data routine analysis for ANAbs in patients with isolated MND is not mandatory.

        • amyotrophic lateral sclerosis
        • motor neuron disease
        • paraneoplastic antineuronal antibodies
        • paraneoplastic neurological syndromes

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