Background: Well characterized antineuronal antibodies (ANAbs) have been shown to be high specific markers for neurological syndromes with a paraneoplastic etiology. Previous reports indicate that pure motor neuron disease (MND) is rarely of paraneoplastic origin.
Objective: To screen systematically for the prevalence of well characterized paraneoplastic ANAbs in a large collective of patients with pure MND.
Methods: In a cohort of 145 patients with MND, the frequency of ANAbs was estimated by ELISA employing recombinant antigens (HuD, Yo, Ri, CV2/CRMP5, Ma2, amphiphysin).
Results: None of the sera revealed high anti-neuronal antigen reactivity. Only in five sera could very low reactivity be detected, in all probability representing background activity.
Conclusion: According to these data routine analysis for ANAbs in patients with isolated MND is not mandatory.
- amyotrophic lateral sclerosis
- motor neuron disease
- paraneoplastic antineuronal antibodies
- paraneoplastic neurological syndromes