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Effects of subthalamic nucleus stimulation and levodopa on autonomic nervous system in Parkinson`s disease
  1. J Ludwig (j.ludwig{at}neurologie.uni-kiel.de)
  1. University Hospital of Kiel, Germany, Germany
    1. P Remien
    1. University Hospital of Kiel, Germany, Germany
      1. C Guballa
      1. University Hospital of Kiel, Germany, Germany
        1. A Binder (a.binder{at}neurologie.uni-kiel.de)
        1. University Hospital of Kiel, Germany, Germany
          1. S Binder
          1. University Hospital of Kiel, Germany, Germany
            1. J Schattschneider
            1. University Hospital of Kiel, Germany, Germany
              1. J Herzog
              1. University Hospital of Kiel, Germany, Germany
                1. J Volkmann
                1. University Hospital of Kiel, Germany, Germany
                  1. G Deuschl
                  1. University Hospital of Kiel, Germany, Germany
                    1. G Wasner
                    1. University Hospital of Kiel, Germany, Germany
                      1. R Baron
                      1. University Hospital of Kiel, Germany, Germany

                        Abstract

                        Autonomic dysfunction is common in Parkinson`s disease (PD).Amongst others, levodopa alteres cardiovascular reflexes.Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment for motor disability in patients with long-lasting PD. Since the basal ganglia are connected to areas involved in regulation of the autonomic nervous system (ANS)STN-DBS might affect ANS functions. This study aimed to investigate the influence of STN-DBS on ANS compared to effects of levodopa administration.

                        • Parkinson`s disease
                        • autonomic nervous system
                        • blood pressure
                        • levodopa
                        • subthalamic nucleus stimulation

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