The role of amyloid metabolism in the pathophysiology of FTLD remains to be elucidated. We compared CSF levels of amyloid beta 1-40 (Aβ40) and amyloid beta 1-42 (Aβ42) in patients with frontotemporal lobar degeneration (FTLD, n=21) versus patients with Alzheimer’s disease (AD, n=39) and control subjects (n=30). While in AD cases Aβ42 levels were lower and CSF Aβ40 levels equal to those in controls, a significant decrease in Aβ40 and increase in CSF Aβ42/Aβ40 ratio was observed in FTLD compared AD and control subjects. These findings favour a differential involvement of amyloid β peptides in FTLD compared to AD.
- Alzheimer's disease
- Cerebrospinal fluid
- amyloid beta
- frontotemporal lobar degeneration