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Estimated life expectancy of Parkinson’s patients compared to the United Kingdom population
  1. Lianna S Ishihara (l.ishihara.01{at}cantab.net)
  1. University of Cambridge, United Kingdom
    1. Anne Cheesbrough (anne.x.cheesbrough{at}gsk.com)
    1. GlaxoSmithKline, United Kingdom
      1. Carol Brayne (carol.brayne{at}phpc.cam.ac.uk)
      1. University of Cambridge, United Kingdom
        1. Anette Schrag (a.schrag{at}medsch.ucl.ac.uk)
        1. Royal Free and University College Medical School, United Kingdom

          Abstract

          Objective: To calculate the best possible estimates for age-specific life expectancy (LE) and anticipated age at the time of death (AAD) in Parkinson′s disease (PD) patients compared to the general population in the United Kingdom (UK). These may be of greater value to patients than standardised mortality ratios (SMRs), which are usually reported in studies on mortality in PD.

          Methods: A literature review identified articles with data on age-stratified life expectancy or SMRs to calculate estimations of LE using the Gompertz function and data on mortality and LE in the UK from the Office of National Statistics and Actuarial Department for the year 2003.

          Results: Two UK studies and four from Western Europe were used to estimate LE and AAD for PD patients from SMRs. The mean LEs of PD patients compared to the general population were: 38(SD5) years for onset between 25-39 years compared to 49(SD 5) years; 21(SD 5) for onset between 40-64 years compared to 31(SD 7) years; 5(SD 4) for onset age ≥65 years compared to 9 (SD 5) years. The average AAD of PD patients with onset between 25-39 years was 71(SD 3) years and considerably lower than that of the general population, 82(SD 2) years. The difference between average AAD for older individuals with PD (onset ≥65 years) and the general population was smaller with an AAD of approximately 88(SD 7) years compared to 91(SD 5) years.

          Conclusions: The calculations showed that LE and AAD in PD are reduced for all onset ages but this reduction is greatest in individuals with young onset. Whilst the results are average estimates, these can provide useful indications of LE and AAD.

          • Parkinson disease
          • gompertz equation
          • life expectancy
          • mortality
          • survival

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