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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp.2006.111609

Hyperacusis in patients with complex regional pain syndrome related dystonia

  1. M J M de Klaver (m.j.m.de_klaver{at}lumc.nl)
  1. Leiden University Medical Center, Netherlands
    1. M A van Rijn (m.a.van_rijn{at}lumc.nl)
    1. Leiden University Medical Center, Netherlands
      1. J Marinus (j.marinus{at}lumc.nl)
      1. Leiden University Medical Center, Netherlands
        1. W Soede (w.soede{at}lumc.nl)
        1. Leiden University Medical Center, Netherlands
          1. J A P M de Laat (japmdelaat{at}lumc.nl)
          1. Audiological Centre, Leiden University Medical Center, Netherlands
            1. J J van Hilten (j.j.van_hilten.neurology{at}lumc.nl)
            1. Leiden University Medical Center, Netherlands
              • Published Online First 30 April 2007

              Abstract

              Introduction: In complex regional pain syndrome type 1 (CRPS-1), patients may have manifestations of central involvement, including allodynia, hyperalgesia or dystonia. We noted that more severely affected patients may experience hyperacusis, which may also reflect central involvement. Aim of this study is to evaluate the occurrence and characteristics of hyperacusis in patients with CRPS related dystonia.

              Methods: Presence of hyperacusis, speech reception thresholds (SRT), pure-tone thresholds (PTT) and uncomfortable loudness (UCL) were evaluated in 40 patients with CRPS-related dystonia.

              Results: PTT and SRT were normal for all patients. Fifteen patients (38%) reported hyperacusis and this was associated with allodynia/hyperalgesia and with more affected extremities. UCLs of patients with hyperacusis were significantly lower than UCLs of patients without hyperacusis.

              Conclusion: Hyperacusis is common among severely affected patients with CRPS related dystonia and may indicate that the disease spreads beyond those circuits related to sensory-motor processing of extremities.

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                1. jnnp.2006.111609v1
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