We applied optimized voxel-based morphometry (VBM) to brain MRIs from autopsy-proven cases of tau-positive frontotemporal lobar degeneration (FTLD-T, N = 6), ubiquitin and TDP-43-positive/tau-negative FTLD (FTLD-U, N = 8) and cognitively normal controls (N = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region-of-interest (ROI) tracing of caudate and putamen volumes confirmed the VBM findings. These anatomic differences may help distinguish between FTLD spectrum pathologic subtypes in vivo.
- Basal ganglia
- Tau-positive frontotemporal lobar degeneration
- Ubiquitin and TDP-43-positive/tau-negative frontotemproal lobar degeneration
- Voxel-based morphometry