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Patterns of MRI atrophy in tau-positive and ubiquitin-positive frontotemporal lobar degeneration
  1. E J Kim (ejkim{at}memory.ucsf.edu)
  1. Departments of Neurology, University of California, San Francisco, United States
    1. G D Rabinovici (grabinovici{at}memory.ucsf.edu)
    1. Departments of Neurology, University of California, San Francisco, United States
      1. W W Seeley (bseeley{at}memory.ucsf.edu)
      1. Departments of Neurology, University of California, San Francisco, United States
        1. C Halabi (chalabi{at}memory.ucsf.edu)
        1. Departments of Neurology, University of California, San Francisco, United States
          1. H Shu (hshu{at}memory.ucsf.edu)
          1. Departments of Neurology, University of California, San Francisco, United States
            1. M W Weiner (mweiner{at}itsa.ucsf.edu)
            1. Department of Radiology, University of California, San Francisco, United States
              1. S J DeArmond (stephen.dearmond{at}ucsf.edu)
              1. Department of Pathology, University of California, San Francisco, United States
                1. J Q Trojanowski (trojanow{at}mail.med.upenn.edu)
                1. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, United States
                  1. M L Gorno-Tempini (marilu{at}memory.ucsf.edu)
                  1. Departments of Neurology, University of California, San Francisco, United States
                    1. B L Miller (bmiller{at}memory.ucsf.edu)
                    1. Departments of Neurology, University of California, San Francisco, United States
                      1. H J Rosen (hrosen{at}memory.ucsf.edu)
                      1. Departments of Neurology, University of California, San Francisco, United States

                        Abstract

                        We applied optimized voxel-based morphometry (VBM) to brain MRIs from autopsy-proven cases of tau-positive frontotemporal lobar degeneration (FTLD-T, N = 6), ubiquitin and TDP-43-positive/tau-negative FTLD (FTLD-U, N = 8) and cognitively normal controls (N = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region-of-interest (ROI) tracing of caudate and putamen volumes confirmed the VBM findings. These anatomic differences may help distinguish between FTLD spectrum pathologic subtypes in vivo.

                        • Basal ganglia
                        • Region-of-interest
                        • Tau-positive frontotemporal lobar degeneration
                        • Ubiquitin and TDP-43-positive/tau-negative frontotemproal lobar degeneration
                        • Voxel-based morphometry

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