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Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004
  1. Orna O'Toole (ooroole{at}rcsi.ie)
  1. Beaumont Hospital, Dublin, Ireland, Republic of Ireland
    1. Bryan J Traynor (traynorb{at}mail.nih.gov)
    1. National Institutes of Health, United States
      1. Paul Brennan (brennanp9{at}gmail.com)
      1. Beaumont Hospital, Dublin, Ireland, Republic of Ireland
        1. Colm Sheehan (colmsheehan{at}gmail.com)
        1. Beaumont Hospital, Dublin, Ireland, Republic of Ireland
          1. Eithne Frost (eithne{at}iolfree.net)
          1. Irish Motor Neurone Disease Association, Dublin, Ireland, Republic of Ireland
            1. Bernie Corr (berniecorr{at}eircom.ie)
            1. Beaumont Hospital, Dublin, Ireland, Republic of Ireland
              1. Orla Hardiman (ohard{at}iol.ie)
              1. Beaumont Hospital, Republic of Ireland

                Abstract

                Objective: The authors conducted a prospective, population-based study to examine trends in incidence and prevalence of ALS in Ireland from 1995 to 2004.

                Methods: The Irish ALS Register was used to identify Irish residents diagnosed with ALS between the three year period from January 1st, 1995 to December 31st 1997 and the three year period from January 1st, 2002 to December 31st, 2004.

                Results: 465 Irish residents were diagnosed with ALS during the study periods. Annual incidence rate of ALS in Ireland remained stable over this time (2.0 cases per 100,000 person-years; 95% CI: 1.9, 2.2). Median survival of Irish ALS patients was 16.4 months and did not change during the study period.

                Conclusion: Demographics and clinical features of the incident and prevalent Irish ALS cohorts were markedly different.

                • Ireland
                • amyotrophic lateral sclerosis
                • incidence
                • prevalence

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