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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp.2007.116038

Factors influencing surgical outcome in patients with focal cortical dysplasia

  1. Susanne Fauser (susanne.fauser{at}uniklinik-freiburg.de)
  1. Epilepsy Centre, University of Freiburg, Germany, Germany
    1. Thomas Bast
    1. Department of Pediatric Neurology, University of Heidelberg, Germany, Germany
      1. Dirk-Matthias Altenmüller
      1. Epilepsy Centre, University of Freiburg, Germany, Germany
        1. Jürgen Schulte-Mönting
        1. Faculty for Mathematics and Physics, University of Freiburg, Germany, Germany
          1. Karl Strobl
          1. Epilepsy Centre Kork, Kehl-Kork, Germany, Germany
            1. Bernhard J Steinhoff
            1. Epilepsy Centre Kork, Kehl-Kork, Germany, Germany
              1. Josef Zentner
              1. Department of Neurosurgery, University of Freiburg, Germany, Germany
                1. Andreas Schulze-Bonhage
                1. Epilepsy Centre, University of Freiburg, Germany, Germany
                  • Published Online First 6 August 2007

                  Abstract

                  120 patients with histologically proven focal cortical dysplasias (FCD) were retrospectively analysed regarding prognostic factors for successful epilepsy surgery. Multivariate data analyses showed that higher age at epilepsy surgery, the occurrence of secondarily generalised seizures, and a multilobar extend of the dysplasia were significant negative predictors. In univariate analyses, longer duration of epilepsy, the need for intracranial EEG recordings, and incomplete resection of the FCD were factors significantly reducing the change to become seizure-free. Histological subtype of the FCD and age at epilepsy onset had no significant predictive value. These findings strongly suggest early consideration of epilepsy surgery in FCD-patients.

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