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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp.2007.122010

Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson’s disease

  1. Rocco Agostino (roccoag55{at}libero.it)
  1. University of Rome, Italy
    1. Loredana Dinapoli (loredana.dinapoli{at}uniroma1.it)
    1. University of Rome, Italy
      1. Nicola Modugno (nicmod{at}tiscali.it)
      1. University of Rome, Italy
        1. Ennio Iezzi (ennio.iezzi{at}neuromed.it)
        1. University of Rome, Italy
          1. Pantaleo Romanelli (pantaleo{at}stanford.edu)
          1. University of Rome, Italy
            1. Alfredo Berardelli (alfredo.berardelli{at}uniroma1.it)
            1. University of Rome, Italy
              • Published Online First 6 August 2007

              Abstract

              In Parkinson’s disease, unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN), unlike bilateral stimulation, excludes ipsilateral confounding effects so that the contralateral effects of DBS on motor performance can be investigated alone. Because no kinematic study has yet investigated how unilateral STN-DBS affects the performance of a contralateral fast sequential motor act, in 10 parkinsonian patients we performed a kinematic analysis of the movement duration, switching time and spatial accuracy of a motor arm sequence. Patients were studied without dopaminergic therapy and when they were OFF and ON unilateral STN-DBS. We found that unilateral STN-DBS significantly improved movement time of a motor sequence and the switching time from one sequential step to the next, whereas accuracy deteriorated. We conclude that unilateral STN-DBS improves the performance of contralateral sequential arm movements in patients with Parkinson’s disease.

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