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The utility of the Cambridge behavioural inventory in neurodegenerative disease
  1. Catherine Wedderburn
  1. Cambridge Centre for Brain Repair, United Kingdom
    1. Helen Wear
    1. Cambridge Centre for Brain Repair, United Kingdom
      1. Joanne Brown
      1. Cambridge Centre for Brain Repair, United Kingdom
        1. Sarah J Mason
        1. Cambridge Centre for Brain Repair, United Kingdom
          1. Roger A Barker
          1. Cambridge Centre for Brain Repair, United Kingdom
            1. John Hodges (john.hodges{at}mrc-cbu.cam.ac.uk)
            1. MRC Cognition & Brain Sciences Unit, United Kingdom
              1. Caroline Williams-Gray
              1. Cambridge Centre for Brain Repair, United Kingdom

                Abstract

                We investigated the utility of the Cambridge Behavioural Inventory (CBI), a carer-completed questionnaire, in a large cohort with Parkinson’s disease (PD) (n=215). In a sub-cohort of 112 PD patients, the CBI was found to be a valid instrument compared to the Neuropsychiatric Inventory, PDQ-39 and UPDRS, with high internal consistency. Furthermore, in the whole cohort, the CBI was sensitive to changes in behaviour with disease progression. Comparison between CBI scores in PD and other neurodegenerative diseases including Huntington’s disease (HD) (n=75), Alzheimer’s disease (AD) (n=96) and frontal variant frontotemporal dementia (fvFTD) (n=64) revealed distinct profiles for each disease. Predominant deficits were ‘sleep’ and ‘self care’ in PD; ‘memory’ in HD and AD; and ‘motivation’ and ‘stereotypic behaviours’ in fvFTD. The CBI is a robust, easy to use and valid instrument, which has the capacity to discriminate between neurodegenerative diseases, and may be of value in monitoring therapeutic interventions.

                • Alzheimer's disease
                • Cambridge Behavioural Inventory
                • Frontotemporal dementia
                • Huntington's disease
                • Parkinson's disease

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