Article Text

other Versions

PDF
Variability in language recovery after first-time Stroke
  1. Ronald M Lazar (ral22{at}columbia.edu)
  1. Columbia University College of Physicians & Surgeons, United States
    1. Allison E Speizer (allisongeller{at}gmail.com)
    1. Columbia University College of Physicians & Surgeons, United States
      1. Joanne R Festa (jfesta{at}neuro.columbia.edu)
      1. Columbia University College of Physicians & Surgeons, United States
        1. John W Krakauer (tropiques{at}aol.com)
        1. Columbia University College of Physicians & Surgeons, United States
          1. Randolph S Marshall (rsm2{at}columbia.edu)
          1. Columbia University College of Physicians & Surgeons, United States

            Abstract

            Background:Predicting aphasia recovery after stroke has been difficult because of substantial variability in outcomes. Few studies have characterized the nature and extent of recovery, beginning with baselines at 24-72 hours after stroke onset.

            Aim:To characterize the course of language recovery after first-time stroke.

            Methods:Using our Performance and Recovery in Stroke Study (PARIS) database, we evaluated consecutive first-time stroke patients with aphasia and DWI-positive lesions on admission and at 90 days.

            Results:Twenty-two of 91 patients had language disorders. Initial syndrome scores were positively correlated with 90-days scores (r = .60) and negatively correlated with the change score from baseline to follow-up ( r = -.66). Neither lesion size, age nor education correlated with initial syndrome severity or with performance at 90 days. Level of education was not associated with degree of recovery. A multiple regression model that combined lesion size, age and initial syndrome was significant (p = .03) but only explained 29% of the variance. Patients with severe deficits at baseline in individual language domains could recover, improve to a less severe deficit, or not improve at all.

            Conclusion:There was significant variability in language recovery after first-time stroke, even in more severe, initial syndromes. Traditional predictors of post-stroke language outcomes did not reliably predict function at 90 days. These data suggest other factors have not yet been identified that account for functional stroke recovery.

            • aphasia
            • recovery of function
            • stroke

            Statistics from Altmetric.com

            Request permissions

            If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.