Background: Loss of insight is a core diagnostic feature of frontotemporal dementia (FTD) and anosognosia is frequently reported in Alzheimer’s disease (AD) Aim: To compare unawareness (anosognosia) for different symptoms, measured with a discrepancy score between patient’s and caregiver’s assessment, in AD and FTD.
Method: In a prospective multicenter study, 123 probable AD patients, selected according to NINCDS-ADRDA procedure, were matched for age, sex, education, disease duration and dementia severity to FTD subjects (n=41), selected according to international consensus criteria. A research complaint questionnaire was used to obtained patient’s and caregiver’s assessment concerning neuropsychological and behavioral symptoms. Data were compared in each group and between groups. Unawareness (measured by discrepancy scores) was compared between AD and FTD patients.
Results: The caregivers generally assessed symptoms more severely than patients did, but both patients groups reported changes in affect (depressive mood or irritability) as their caregivers did. Unawareness was greater in FTD than in AD patients for language and executive difficulties, and for changes in behavior and daily activities.
Conclusion: The main finding is that unawareness was observed in both FTD and AD patients for most clinical domains. However, qualitative and quantitative differences showed that lack of awareness was greater in FTD subjects
- frontotemporal dementia
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.