Article Text

other Versions

Corticobasal syndrome due to a thalamic tuberculoma and focal cortical atrophy
  1. Kandadai Rukmini Mridula (rukminimridula{at}
  1. Nizam's Institute of Medical Sciences, Hyderabad, India
    1. Suvarna Alladi (alladisuvarna{at}
    1. Nizam's Institute of Medical Sciences, Hyderabad, India
      1. Dandu Ravi Varma (varmaji{at}
      1. Krishna Institute of Medical Sciences, Hyderabad, India
        1. Jaydip Ray Chaudhuri (jaydiprc{at}
        1. Kamineni Institute of Medical Sciences,Hyderabad, India
          1. Yarlagadda Jyotsna
          1. Nizams Institute of Medical Sciences, India
            1. Rupam Borgohain
            1. Nizams Institute of Medical sciences, Hyderabad, India
              1. Subhash Kaul (subashkaul{at}
              1. Nizam's Institute of Medical Sciences, India


                Corticobasal syndrome (CBS) is a clinical entity characterised by asymmetric extrapyramidal features, cortical signs and focal cortical atrophy. Although CBS is classically described as a tauopathy, recent reports demonstrate considerable pathologic heterogeneity in patients with clinical profile of CBS. We report a patient with posterior thalamic tuberculoma who developed clinical features of CBS as the lesion resolved. Sequential MRI revealed progressive atrophy of the ipsilateral parietotemporal cortex. Hypometabolism of the posterior thalamus and the involved parietotemporal cortex was demonstrated on 18-FDG PET, while diffusion tensor imaging revealed degeneration of the superior and posterior thalamic radiations. We propose that the focal cortical atrophy in this case is secondary to destruction of thalamic nuclei, Wallerian degeneration of the thalamocortical radiations and subsequent trans-synaptic neuronal degeneration. Our case further extends the etiological spectrum of clinical presentation of CBS.

                • corticobasal syndrome
                • focal cortical atrophy
                • tuberculoma

                Statistics from

                Request permissions

                If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.