Article Text

other Versions

PDF
The effects of subthalamic deep brain stimulation on noun/verb generation and selection from competing alternatives in Parkinson’s disease
  1. Joanna E Castner (j.castner{at}uq.edu.au)
  1. The University of Queensland, Australia
    1. Helen J Chenery (h.chenery{at}uq.edu.au)
    1. University of Queensland, Australia
      1. Peter A Silburn (pa{at}silburn.com.au)
      1. St. Andrew's War Memorial Hospital and The Wesley Hospital, Australia
        1. Erin R Smith (e.smith{at}shrs.uq.edu.au)
        1. The University of Queensland, Australia
          1. Terry J Coyne (tcoyne{at}brizbrain.com.au)
          1. St. Andrew's War Memorial Hospital and The Wesley Hospital, Australia
            1. Felicity Sinclair
            1. St. Andrew's War Memorial Hospital and The Wesley Hospital, Australia
              1. David A Copland (d.copland{at}uq.edu.au)
              1. The University of Queensland, Australia

                Abstract

                Background: Impaired generation of verbs relative to nouns has been reported in Parkinson's disease (PD) and has been associated with the frontal pathophysiology of PD. This study aimed to measure noun/verb generation abilities in PD and to determine whether noun/verb generation is affected by stimulation of the subthalamic nucleus (STN).

                Methods: Eight participants who had been diagnosed with PD and had received surgery for deep brain stimulation (DBS) of the STN as well as 15 control participants completed a noun/verb generation task with four probe-response conditions; namely noun-noun, verb-noun, noun-verb, and verb-verb conditions. PD participants were assessed whilst receiving STN stimulation and without stimulation.

                Results: During the off stimulation condition, PD participants presented with a selective deficit in verb generation compared with control participants. However, when receiving STN stimulation, PD participants produced significantly more errors than controls during the noun-noun and verb-verb conditions. For PD participants, errors during verb generation were significantly correlated with item selection constraint (i.e., the degree to which a response competes with other response alternatives) in the on stimulation condition, but not the off stimulation condition.

                Conclusions: STN stimulation modulates a frontotemporal network associated with word generation and affects the ability to select from many competing lexical alternatives during verb generation.

                • action fluency
                • inferior frontal gyrus
                • prefrontal cortex
                • verbal fluency
                • word generation

                Statistics from Altmetric.com

                Request permissions

                If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.