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Gabapentin for prevention of hypobaric hypoxia-induced headache: Randomized double-blind clinical trial
  1. Sirous Jafarian (jafarian_s{at}yahoo.com)
  1. Department of Neurology, Shariati Hospital, Medical Sciences/University of Tehran, Iran, Islamic Republic of
    1. Roya Abolfazli (abolfazl{at}sina.tums.ac.ir)
    1. Department of Neurology, Amiralam Hospital, Medical Sciences/University of Tehran, Iran, Islamic Republic of
      1. Farzam Gorouhi (gorouhif{at}gmail.com)
      1. Department of Neurology, Shariati Hospital, Medical Sciences/University of Tehran, Iran, Islamic Republic of
        1. Sepideh Rezaie (sepidarir{at}yahoo.com)
        1. Department of Neurology, Shariati Hospital, Medical Sciences/University of Tehran, Iran, Islamic Republic of
          1. Jamshid Lotfi (lotfi99{at}yahoo.com)
          1. Department of Neurology, Shariati Hospital, Medical Sciences/University of Tehran, Iran, Islamic Republic of

            Abstract

            Background: High-altitude headache (HAH) is a hypobaric hypoxia-induced symptom which is commonly experienced by newcomers to high-altitude areas. Objective: To assess the efficacy of gabapentin in prevention of HAH.

            Methods: A placebo-controlled randomized trial was performed at an altitude of 3500 meters. Two hundred and four unacclimatized 15 to 65 years old (mean age[±SD], 31.5±11.7) hotel guests were randomly assigned to a 600mg single-dose of gabapentin capsule or identical placebo. HAH incidence and intensity were measured to assess gabapentin efficacy. Intention to treat analysis was performed.

            Results: The incidence of HAH was not significantly different between subjects under gabapentin (44[43.1%]) compared with placebo (56[54.9%]; р=0.09). In contrast, moderate/severe HAH had lower incidence in gabapentin group (27[26.5%) versus placebo group (42[41.2%]) showing that gabapentin reduced HAH attack intensity (р=0.03).

            Conclusions: Gabapentin was effective for prevention of HAH and had satisfactory tolerability. (controlled-trials.com identifier:ISRCTN26123577)

            • acute mountain sickness
            • gabapentin
            • high-altitude headache
            • hypobaric hypoxia

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