BackgroundTo investigate the effect of carrying the APOE-∊4 allele on global functional outcome, on activity limitations and participation restrictions, and on community integration at 3, 6, 12, 18, 24, and 36 months after traumatic brain injury.
Method: The Glasgow Outcome Scale (GOS), the Sickness Impact Profile-68 (SIP-68), and the Community Integration Questionnaire (CIQ) were assessed in 79 moderate and severe traumatic brain injury patients at 3, 6, 12, 18, 24, and 36 months post-injury. Repeated measures analyses of variance were performed with APOE-∊4 status and time of measurement as independent variables and the GOS, SIP-68, and CIQ as dependent variables. Analyses were adjusted for baseline age, gender, and the Glasgow Coma Score.
Results: Patients with the APOE-∊4 allele had a significantly better global functional outcome on the GOS than patients without the APOE-∊4 allele. No significant associations were found between APOE-∊4 status and the SIP-68 and CIQ.
Discussion: In contrast to other studies, we found that carrying the APOE-∊4 allele had a protective influence on outcome. Multiple mechanisms, and in some cases competitive mechanisms, may explain the variable relation between the APOE-∊4 allele and outcome after traumatic brain injury.
- Apolipoprotein E4
- craniocerebral trauma
- traumatic brain injury