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Imaging language pathways predicts postoperative naming deficits
  1. H W Robert Powell (robpowell{at}doctors.org.uk)
  1. Institute of Neurology, United Kingdom
    1. Geoff J M Parker (geoff.parker{at}manchester.ac.uk)
    1. University of Manchester, United Kingdom
      1. Daniel C Alexander (d.alexander{at}cs.ucl.ac.uk)
      1. University College London, United Kingdom
        1. Mark R Symms (m.symms{at}ion.ucl.ac.uk)
        1. Institute of Neurology, United Kingdom
          1. Philip A Boulby (p.boulby{at}ion.ucl.ac.uk)
          1. Institute of Neurology, United Kingdom
            1. Gareth J Barker (g.barker{at}iop.kcl.ac.uk)
            1. Kings College London, United Kingdom
              1. Pam J Thompson (pam.thompson{at}epilepsynse.org.uk)
              1. Institute of Neurology, United Kingdom
                1. Matthias J Koepp (m.koepp{at}ion.ucl.ac.uk)
                1. Institute of Neurology, United Kingdom
                  1. John S Duncan (j.duncan{at}ion.ucl.ac.uk)
                  1. Institute of Neurology, United Kingdom

                    Abstract

                    Naming difficulties are a well recognised, but difficult to predict, complication of anterior temporal lobe resection (ATLR) for refractory epilepsy. We used magnetic resonance (MR) tractography pre-operatively to demonstrate the structural connectivity of language areas in patients undergoing dominant hemisphere ATLR. Greater lateralisation of tracts to the dominant hemisphere was associated with greater decline in naming function. We suggest that this method has the potential to predict language deficits in patients undergoing ATLR.

                    • Anterior temporal lobe resection
                    • Language
                    • MR-tractography
                    • Temporal lobe epilepsy

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