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Self-perceived memory impairment and cognitive performance in an elderly independent population with age-related white matter changes
  1. Bruno Miranda (bruno.a.miranda{at}gmail.com)
  1. Serviço de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
    1. Sofia Madureira (smadureira{at}hotmail.com)
    1. Serviço de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
      1. Ana Verdelho (averdelho{at}netcabo.pt)
      1. Serviço de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
        1. José M Ferro (jmferro{at}fm.ul.pt)
        1. Serviço de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
          1. Leonardo Pantoni
          1. Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
            1. Emilia Salvadori
            1. Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
              1. Hugues Chabriat
              1. Department of Neurology, Hôpital Lariboisière, Paris, France
                1. Timo Erkinjuntti
                1. Memory Research Unit, Department of Clinical Neurosciences, Helsinki University, Helsinki, Finland
                  1. Franz Fazekas
                  1. Department of Neurology and MRI Institute, Karl Franzens University Graz, Graz, Austria
                    1. Michael Hennerici
                    1. Department of Neurology, University of Heidelberg, Klinikum Mannheim, Mannheim, Germany
                      1. John O’Brien
                      1. Institute for Ageing and Health, University of Newcastle, Newcastle-upon-Tyne, United Kingdom
                        1. Philip Scheltens
                        1. Department of Neurology, VU Medical Center, Amsterdam, Netherlands
                          1. Marieke C. Visser
                          1. Department of Neurology, VU Medical Center, Amsterdam, Netherlands
                            1. Lars-Olof Wahlund
                            1. Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University, Sweden
                              1. Gunhild Waldemar
                              1. Memory Disorders Research Unit, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark
                                1. Anders Wallin
                                1. Institute of Clinical Neuroscience, Göteborg University, Göteborg, Sweden
                                  1. Domenico Inzitari
                                  1. Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy

                                    Abstract

                                    Objectives: To determine whether self-perceived memory impairment is associated with the severity of white matter changes (WMC) and is related to cognitive impairment. Methods: Data were drawn from the multinational leukoaraiosis and disability (LADIS) study which investigates the impact of WMC on global functioning. WMC severity was rated using the Fazekas scale. Medial temporal lobe atrophy (MTA) was scored visually and values were meaned. The neuropsychological battery consisted of the Mini-Mental State Examination, a modified version of the VADAS-Cog, Trail making and Stroop tests. A question about self-perceived memory impairment was used as a measure for presence of memory complaints. Cognitive performance was analysed test-by-test and in three main domains: memory, executive functions and speed/motor control. The Geriatric Depression Scale (GDS) was used as measure of depressive symptoms. Results: Six hundred and thirty-eight subjects were included in this study. No association was found between memory complaints and the severity of WMC. Subjects with memory complaints (n=399) had a higher GDS score [t(637) = -7.15; P < 0.02] and performed worse on almost all cognitive tests and on the three cognitive domains. Multiple linear regression showed that the worse performance on the memory domain was associated with memory complaints independently of depressive symptoms, WMC severity and MTA (R2 = 0.183; F = 17.09, β = -0.126; P < 0.05). Conclusion: In a sample of non-disabled elderly subjects with WMC, self-perceived memory impairment is significantly associated with objective memory impairment independently of the WMC severity, depressive symptoms and MTA.

                                    • Aging
                                    • Cognition
                                    • Depression
                                    • Memory complaints
                                    • White matter changes

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