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Topiramate, nutrition and weight change: a prospective study
  1. Karl Martin Klein (klein.km{at}staff.uni-marburg.de)
  1. Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Marburg, Germany, Germany
    1. Frank Theisen
    1. Interdisciplinary Epilepsy-Center, Department of Child and Adolescent Psychiatry, Philipps Universit, Germany
      1. Susanne Knake
      1. Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Marburg, Germany, Germany
        1. Wolfgang H. Oertel
        1. Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Marburg, Germany, Germany
          1. Johannes Hebebrand
          1. Department of Child and Adolescent Psychiatry, University Duisburg-Essen, Germany, Germany
            1. Felix Rosenow
            1. Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Marburg, Germany, Germany
              1. Hajo M. Hamer
              1. Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Marburg, Germany, Germany

                Abstract

                Purpose: To evaluate prospectively the relationship between appetite, food composition, nutritional habits and weight loss under topiramate (TPM) and to identify predictors for TPM induced weight loss.

                Methods: 22 epilepsy patients who were started on TPM were prospectively followed for six months and contacted again after a mean follow-up time of 37.1 months.

                Results: BMI loss occurred in 59% of the patients with a mean weight loss of 9.5 kg after 6 months on TPM without further weight loss at long term follow-up. Weight loss went along with reduction in appetite without affecting food composition. Predictors for BMI loss after 6 months were high initial BMI and body fat. At 3 weeks on TPM, the recorded parameters did not predict BMI loss but at 3 months weight loss, reduction of appetite and amount of food intake were predictive for the amount of BMI loss after 6 months.

                • adverse effects
                • antiepileptic agents
                • body fat
                • food composition
                • weight loss

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