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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp.2007.125401

Combined EEG-fMRI and tractography to visualise propagation of epileptic activity.

  1. Khalid Hamandi (hamandik{at}cardiff.ac.uk)
  1. University Hospital of Wales, United Kingdom
    1. H.W.Robert Powell (robpowell{at}doctors.org.uk)
    1. Institute of Neurology, United Kingdom
      1. Helmut Laufs (helmut{at}laufs.com)
      1. Johann Wolfgang Goethe-University Frankfurt am Main, Germany
        1. Mark R Symms (m.symms{at}ion.ucl.ac.uk)
        1. Department of Clinical and Experimental Epilepsy, United Kingdom
          1. Gareth J Barker (g.barker{at}iop.kcl.ac.uk)
          1. Institute of Psychiatry, United Kingdom
            1. Geoff JM Parker (geoff.parker{at}manchester.ac.uk)
            1. Imaging Science & Biomedical Engineering, United Kingdom
              1. Louis Lemieux (l.lemieux{at}ion.ucl.ac.uk)
              1. Institute of Neurology, United Kingdom
                1. J S Duncan (j.duncan{at}ion.ucl.ac.uk)
                1. Natl Hosp for Neurology & Neurosurgery, United Kingdom
                  • Published Online First 20 December 2007

                  Abstract

                  In a patient with refractory temporal lobe epilepsy, EEG-fMRI showed activation in association with left anterior temporal interictal discharges, in the left temporal, parietal and occipital lobes. Dynamic causal modeling suggested propagation of neural activity from the temporal focus to the area of occipital activation. Tractography showed connections from the site of temporal lobe activation to the site of occipital activation. This demonstrates the principle of combining EEG-fMRI and tractography to delineate the pathways of propagation of epileptic activity.

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