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Functional imaging correlates of fronto-temporal dysfunction in Morvan’s syndrome
  1. Ahmed T Toosy (a.toosy{at}ion.ucl.ac.uk)
  1. Department of Neurology, 3rd Floor, Lambeth Wing, St Thomas’s Hospital, London SE1 7EH, United Kingdom
    1. Sophie E Burbridge (sophieburbridge{at}doctors.org.uk)
    1. Department of Neurology, 3rd Floor, Lambeth Wing, St Thomas’s Hospital, London SE1 7EH, United Kingdom
      1. Mervi Pitkanen (pitkanenmer{at}hotmail.com)
      1. Neuropsychiatry and Memory Disorders Clinic & King’s College London/Institute of Psychiatry, London, United Kingdom
        1. Alice S Loyal (alice.loyal{at}awp.nhs.uk)
        1. Neuropsychiatry and Memory Disorders Clinic & King’s College London/Institute of Psychiatry, London, United Kingdom
          1. Nozomi Akanuma (nozomi.akanuma{at}kcl.ac.uk)
          1. Neuropsychiatry and Memory Disorders Clinic & King’s College London/Institute of Psychiatry, London, United Kingdom
            1. Hana Laing (hana.laing{at}gstt.nhs.uk)
            1. Neuropsychiatry and Memory Disorders Clinic & King’s College London/Institute of Psychiatry, London, United Kingdom
              1. Michael D Kopelman (michael.kopelman{at}kcl.ac.uk)
              1. Neuropsychiatry and Memory Disorders Clinic & King’s College London/Institute of Psychiatry, London, United Kingdom
                1. Thomasin C Andrews (thomasin.andrews{at}gstt.nhs.uk)
                1. Department of Neurology, 3rd Floor, Lambeth Wing, St Thomas’s Hospital, London SE1 7EH, United Kingdom

                  Abstract

                  A previously well 66 year old man presented with a one month history of focal involuntary spasms of his arms and then his left leg, culminating in two generalized convulsions. He also complained of episodic memory problems, sleeping difficulties, daytime somnolence, hyperphagia, hyperhidrosis and erectile impotence. He was treated initially with phenytoin for two months and then valproate. His family noticed increasing dishevelment and emotional lability over the previous six months. His step-daughter reported that he did not drink to excess although 10 years previously, there was heavy alcohol use.

                  • Morvan’s syndrome
                  • Voltage gated potassium channel antibody syndrome
                  • fluoro-deoxy-glucose positron emission tomography
                  • frontal executive dysfunction

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