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Cerebral microbleeds in the population based AGES Reykjavik study: Prevalence and location
  1. Sveinbjornsdottir S (sigurls{at}landspitali.is)
  1. Landspitali University Hospital, Reykjavik, Iceland, Iceland
    1. Sigurdsson S (sigurdur{at}hjarta.is)
    1. The, Iceland
      1. Aspelund T (aspelund{at}hjarta.is)
      1. The Icelandic Heart Association, Iceland
        1. Kjartansson O (olakj{at}landspitali.is)
        1. Landspitali University Hospital, Iceland
          1. Eiriksdottir G (gudny{at}hjarta.is)
          1. The Icelandic Heart Association, Iceland
            1. Valtysdottir B (bylgja{at}hjarta.is)
            1. The Icelandic Heart Association, Iceland
              1. Lopez OL (lopezol{at}upmc.edu)
              1. The University of Pittsburgh, Pennsylvania, USA, United States
                1. van Buchem MA (m.a.van_buchem{at}lumc.nl)
                1. University of Leiden, Netherlands
                  1. Jonsson PV (palmivj{at}landspitali.is)
                  1. Landspitali University Hospital, Iceland
                    1. Gudnason V (v.gudnason{at}hjarta.is)
                    1. The Icelandic Heart Association, Iceland
                      1. Launer LJ (launerl{at}nia.nih.gov)
                      1. National Insitute on Aging/NIH, United States

                        Abstract

                        Background and purpose: Incidental foci of signal loss suggestive of past cerebral microbleeds (CMBs) are frequent findings on gradient echo T2*-weighted MRI (T2*-MRI) of patients with haemorrhagic or ischemic stroke. There are few prevalence data on older populations. We report on the prevalence and location of CMBs in a community-based cohort of older men and women [b. 1907-35], who participated in the AGES-Reykjavik Study, a population based cohort study that followed the Reykjavik Study.

                        Methods: As a part of the exam, all eligible and consenting cohort members underwent a full brain MRI and blood was drawn for genotyping. Results are based on the first 1962 men (n=820) and women (n=1142), mean age 76 years, with complete MRI and demographic information available.

                        Results: Evidence of CMBs was found in 218 participants (11.1% (95% CI 9.8%-12.6%)); men had significantly more CMBs than women (14.4% vs. 8.8%; p=0.0002, age adjusted). The prevalence of CMBs increased with age (p=0.0001) both in men (p=0.006) and women (p=0.007). CMBs were located in the cerebral lobes (70%), the basal ganglia region (10.5%) and infratentorial (18.6%). Having a CMB was significantly associated with a homozygote APO E å4å4 genotype (p=0.008).

                        Conclusion: Cerebral microbleeds are common in older persons. The association with homozygote APO-E å4 genotype and finding a relative predominance in the parietal lobes, might indicate an association with amyloid angiopathy.

                        • angiopathy
                        • apolipoprotein E genotype
                        • cerebral microbleeds
                        • elderly
                        • prevalence

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