Background: Metabolic syndrome (MetS) is associated with an increased risk of ischemic stroke including silent brain infarction. No study has examined its association with the lacunar subtype alone. The present cross-sectional study examined the relations between MetS, its components and silent lacunar infarction (SLI) in middle-aged subjects.
Methods: We studied 2,076 subjects at ages between 40 and 59 years without a past history of stroke and clinical symptoms, who visited a health care facility for a routine health checkup and underwent brain magnetic resonance imaging. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel‡V report. A multiple logistic regression model was used to examine associations between MetS and SLI while adjusting for age, gender, a past history of ischemic heart disease, and current smoking.
Results: MetS was strongly associated with the presence of SLI [adjusted odds ratio (OR), 6.52; 95% confidence interval (CI), 4.30-9.90]. As for MetS components, elevated blood pressure, impaired fasting glucose, hypertriglyceridemia, and large waist circumference were significantly associated with SLI, independently of interrelationship between the components, while low high-density lipoprotein cholesterol was not significantly associated.
Conclusions: MetS was significantly associated with the prevalence of SLI in middle-aged persons. Not only elevated blood pressure and impaired fasting glucose, which are well-known risk factors of SLI, but also hypertriglyceridemia and large waist circumference were independent risk factors of SLI.
- cross-sectional study
- metabolic syndrome
- silent lacunar infarction
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.