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Anti-basal ganglia antibodies and Tourette’s syndrome: A voxel-based morphometry and diffusion tensor imaging study in an adult population
  1. D Martino (davidemartino{at}virgilio.it)
  1. University of Bari, Bari, Italy, Italy
    1. B Draganski
    1. Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, United Kingdom
      1. A Cavanna
      1. Department of Neurology, Amedeo Avogadro University, Novara, Italy
        1. A Church
        1. Department of Neuroimmunology, Institute of Neurology, UCL, London, United Kingdom
          1. G Defazio
          1. Department of Neurological and Psychiatric Sciences, University of Bari, Italy
            1. M M Robertson
            1. St Georges Hospital Medical School, London, United Kingdom
              1. R S J Frackowiak
              1. Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, United Kingdom
                1. G Giovannoni
                1. Department of Neurology, Barts and The London NHS Trust, The Royal London Hospital, London, United Kingdom
                  1. H D Critchley
                  1. Department of Psychiatry, Brighton and Sussex Medical School, Brighton, United Kingdom

                    Abstract

                    Anti-basal ganglia antibodies (ABGA) were suggested as a hallmark of autoimmunity in Gilles de la Tourette’s syndrome (GTS), possibly related to prior exposure to streptococcal infection. In order to detect whether the presence of ABGA was associated with subtle structural changes in GTS, we performed whole brain analysis using independent sets of T1 and diffusion tensor (DTI) magnetic resonance imaging (MRI)-based methods on 22 adults with GTS with (n=9) and without (n=13) detectable ABGA in the serum. Voxel-based morphometry analysis failed to detect any significant difference in gray matter density between ABGA+ and ABGA- groups in both caudate nuclei, putamina, thalami and frontal lobes. These results suggest that ABGA synthesis is not related to structural gray and white matter changes (detectable with these methods) within fronto-striatal circuits.

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