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Long term clinical and PET outcome of foetal striatal transplantation in Huntington's disease
  1. Iris Reuter (iris.reuter{at}neuro.med.uni-giessen.de)
  1. Academic Department of Neuroscience, Kings College Hospital, London, United Kingdom
    1. Yen F Tai (yen.tai{at}imperial.ac.uk)
    1. MRC Clinical Sciences Centre, Imperial College London, Hammermsith Hospital, London, United Kingdom
      1. Nicola Pavese (nicola.pavese{at}imperial.ac.uk)
      1. MRC Clinical Sciences Centre, Imperial College London, Hammermsith Hospital, London, United Kingdom
        1. K Ray Chaudhuri (chaudhuriray{at}hotmail.com)
        1. Academic Department of Neuroscience, Kings College Hospital, London, United Kingdom
          1. Sarah L Mason (slm64{at}cam.ac.uk)
          1. Cambridge Centre for Brain Repair and Department of Neurology, United Kingdom
            1. Charles E Polkey (polkeyce{at}aol.com)
            1. Academic Department of Neuroscience, Kings College Hospital, London, United Kingdom
              1. Chris Clough (chris.clough{at}rcplondon.ac.uk)
              1. Academic Department of Neuroscience, Kings College Hospital, London, United Kingdom
                1. David J Brooks (david.brooks{at}imperial.ac.uk)
                1. MRC Clinical Sciences Centre, Imperial College London, Hammermsith Hospital, London, United Kingdom
                  1. Roger A Barker (rab46{at}cam.ac.uk)
                  1. Cambridge Centre for Brain Repair and Department of Neurology, United Kingdom
                    1. Paola Piccini (paola.piccini{at}imperial.ac.uk)
                    1. MRC Clinical Sciences Centre, Imperial College London, Hammermsith Hospital, London, United Kingdom

                      Abstract

                      Two patients with moderate Huntington’s disease (HD) received bilateral foetal striatal allografts. One patient demonstrated, for the first time, increased striatal D2-receptor binding evident with 11C-raclopride PET and prolonged clinical improvement over five years, suggesting long-term survival and efficacy of the graft. The other patient did not improve clinically or radiologically. Our results indicate that striatal transplantation in HD may be beneficial, but further studies are needed to confirm this.

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