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Narcolepsy in Southern Chinese- Clinical Characteristics, HLA Typing and Seasonality of Birth
  1. Wing YK (ykwing{at}cuhk.edu.hk)
  1. The Chinese University of Hong Kong, Hong Kong
    1. Chen L
    1. The Chinese University of Hong Kong, Hong Kong
      1. Fong SYY
      1. The Chinese University of Hong Kong, Hong Kong
        1. Ng MHL
        1. The Chinese University of Hong Kong, Hong Kong
          1. Ho CKW
          1. The Chinese University of Hong Kong, Hong Kong
            1. Cheng SH
            1. The Chinese University of Hong Kong, Hong Kong
              1. Tang NLS
              1. The Chinese University of Hong Kong, Hong Kong
                1. Li AM
                1. The Chinese University of Hong Kong, Hong Kong

                  Abstract

                  Objective: To report clinical characteristics, HLA typing and seasonality of birth of a series of fifty-four Southern Chinese suffering from narcolepsy.

                  Methods: All subjects underwent detailed medical and psychiatric interviews and a standardized nocturnal PSG followed by a daytime MSLT. Each subject also completed a set of sleep questionnaires. HLA typing was performed in 91% of subjects.

                  Results: Seventy-eight percent and 22% were diagnosed of suffering from cataplectic and non-cataplectic narcolepsy respectively. Majority (n=47, 87%) of patients were referred to our sleep clinic for EDS. The cataplectic narcolepsy differed from non-cataplectics by having more REM-related clinical (more Sleep Paralysis and Sleep-related Hallucination) and sleep disturbances (shorter REM latency) as well as tighter association with HLA DQB1*0602. A bi-modal peak pattern was observed at 11 years and 39 years old. Similar bi-modal pattern also occurred for EDS and cataplexy. Excess winter birth was observed for this series of patients. Eighty-one percent of cataplectic narcolepsy patients were DQB1*0602 positive. There were no difference between early and late onset cases in the association with positive DQB1*0602 (71.4% vs 60%). Narcolepsy has prominent pernicious effects on various social, academic, family and mental aspects in our patients.

                  Conclusions: In our Southern Chinese narcolepsy series, bi-modal peak pattern of age of onset, excess winter birth and tight association of HLA DQB1*0602 with cataplectic narcolepsy were found.

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