Background: The underlying factors of reversion from cognitive impairment to normal cognitive functioning in stroke are not well understood. We compare demographic, cognitive and imaging factors in Vascular Cognitive Impairment No Dementia (Vascular CIND) patients who revert to normal cognitive functioning to Vascular CIND patients who do not revert.
Methods: Thirty-one ischemic stroke patients, who met classification criteria for Vascular CIND, were > 49.5 years old, met NINDS stroke criteria, and were free from additional neurological illness, completed baseline and one year examinations. Forty-five percent of the Vascular CIND participants reverted to no cognitive impairment at one-year follow-up examination.
Results: There was greater cognitive impairment in non-reverters on a summary score spanning several neuropsychological domains and on psychomotor and working memory summary scores. There were no differences on demographic factors or in stroke severity between reverters and nonreverters. Structural MRI analyses revealed no baseline differences in number of strokes, stroke volume, or stroke location. However, there was greater frontal white matter hyperintensity load in the non-reverter group.
Conclusions: These results suggest that Vascular CIND reversion may be a function of a combination of baseline neuropsychological function and location of cerebrovascular disease.