Article Text

other Versions

PDF
Clinical and Electrodiagnostic Findings in Copper Deficiency Myeloneuropathy
  1. Brent P Goodman (goodman.brent{at}mayo.edu)
  1. Mayo Clinic, United States
    1. E Peter Bosch (bosch.peter{at}mayo.edu)
    1. Mayo Clinic, United States
      1. Mark A Ross (ross.mark{at}mayo.edu)
      1. Mayo Clinic, United States
        1. Char Hoffman-Snyder
        1. Mayo Clinic, United States
          1. David D Dodick (dodick.david{at}mayo.edu)
          1. Mayo Clinic Scottsdale, United States
            1. Benn E Smith (smith.benn{at}mayo.edu)
            1. Mayo Clinic, United States

              Abstract

              Introduction: Copper deficiency is an increasingly recognized cause of neurological impairment. This retrospective review highlights clinical and electrodiagnostic findings in patients diagnosed at our institution with copper deficiency.

              Methods: Clinical, radiographic and electrodiagnostic findings were reviewed in patients with evidence of copper deficiency. Patients with other potential causes of myelopathy or neuropathy were excluded.

              Results: The predominant clinical feature in all six patients was a sensory ataxia, resulting in marked gait unsteadiness. Nerve conduction studies and needle EMG were performed in all patients and revealed a mild to moderate distal, axonal, sensorimotor peripheral neuropathy. Median and tibial somatosensory evoked potentials were abnormal in all five patients in which it was done, showing impaired conduction in central or proximal peripheral somatosensory pathways.

              Conclusions:This pattern of electrodiagnostic findings suggests that impairment in somatosensory pathways demonstrated by somatosensory evoked potential testing, is the main cause of the sensory ataxia in patients with copper deficiency.

              Statistics from Altmetric.com

              Request permissions

              If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.