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Evidence of persisting cognitive impairment in a case series of patients with locked-in-syndrome
  1. Marc Rousseaux (mrousseaux{at}
  1. CHRU de Lille, France
    1. Emilie Castelnot
    1. Institut d'orthophonie de Lille, France
      1. Pascal Rigaux
      1. Fondation Hôpale, France
        1. Odile Kozlowski
        1. CHRU de Lille, France
          1. François Danzé
          1. Fondation Hôpale, France


            Objective: Previous researches on cognition and locked-in syndrome (LIS) are limited to single case reports, and usually reported normality of performance. Here, we investigated cognitive disorders in a group of LIS patients, using a specific test relying only on a yes/no response indicated by eye movements or verbally.

            Methods: Nine patients with LIS resulting from brainstem stroke were compared with seven patients with frontal or fronto-temporal lesions and 16 matching normal control subjects. The test comprised 19 subtests of perception (visual and auditory recognition), oral comprehension (identity, words and sentences), written comprehension (words and sentences), orientation (in time and place), immediate and delayed memories (verbal and visuo-spatial information), calculation and problem solving, and analysis of verbal logic.

            Results: LIS patients showed significant difficulties in auditory recognition (associative level), oral comprehension of complex sentences, delayed visuo spatial memory, mental calculation and problem solving. Patients with hemispheric lesions were more severely impaired. Single case analysis revealed that four LIS patients showed cognitive disorders in at least three subtests. These disorders were not related with a specific localization of lesions.

            Conclusions: Moderate and selective cognitive disorders can be observed in LIS patients. Systematic assessment is needed, because of their possible consequences for communication and rehabilitation protocols.

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