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Clinical predictors of mechanical ventilation in Fisher/Guillain-Barre overlap syndrome
  1. Kei Funakoshi (kei-f{at}
  1. Dokkyo Medical University, Japan
    1. Satoshi Kuwabara (kuwabara-s{at}
    1. Chiba University School of Medicine, Japan
      1. Masaaki Odaka (m-odaka{at}
      1. Dokkyo Medical University, Japan
        1. Koichi Hirata (hirata{at}
        1. Dokkyo Medical University, Japan
          1. Nobuhiro Yuki (yuki-gbs{at}
          1. GBS Laboratory, Japan


            Background: Some patients with Fisher syndrome (FS) developed subsequent descending tetraparesis (Fisher/Guillain-Barre overlapping syndrome: FS/GBS). We assume that such descending progression may frequently lead to respiratory failure.

            Objective: To investigate whether patients with FS/GBS more often require artificial ventilation than those with typical GBS and which clinical and serological findings are useful predictors.

            Methods: Medical records were reviewed of patients who manifested acute ophthalmoplegia, ataxia and areflexia, as well as subsequent tetraparesis with monophasic course. Forty-five patients fulfilled the FS/GBS criteria. Clinical and serological features were analyzed, and clinical predictors of mechanical ventilation were investigated.

            Results: FS/GBS patients more frequently required mechanical ventilation than did GBS patients (24% versus 10%, p = 0.04). The former also needed artificial ventilation earlier than the latter (p = 0.03), but none of the FS patients required it. As the initial symptom, ventilated FS/GBS patients more frequently showed titubation than non-ventilated ones (55% versus 18%, p = 0.04). During the illness;f course, descending tetraparesis was more common in 11 ventilated FS/GBS patients than in the other 34 non-ventilated ones (64% versus 21%, p = 0.02). Need for artificial ventilation was associated neither with anti-GQ1b IgG antibodies, monospecific anti-GT1a IgG antibodies nor IgG antibodies to various ganglioside complexes.

            Conclusions: FS/GBS patients significantly needed mechanical ventilation more often. Such patients showing titubation and descending tetraparesis need to be carefully monitored as the illness progresses because those clinical features are helpful predictors of respiratory failure.

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