Article Text

other Versions

PDF
BDNF val66met Influences Time To Onset Of Levodopa-Induced Dyskinesia In Parkinson’s Disease.
  1. Thomas Foltynie (t.foltynie{at}ion.ucl.ac.uk)
  1. Institute of Neurology, United Kingdom
    1. Binith Cheeran (binith{at}mac.com)
    1. Institute of Neurology, United Kingdom
      1. Caroline H Williams-Gray (chm27{at}cam.ac.uk)
      1. University of Cambridge, United Kingdom
        1. Mark John James Edwards (m.edwards{at}ion.ucl.ac.uk)
        1. Institute of Neurology, United Kingdom
          1. Susanne Schneider (s.schneider{at}ion.ucl.ac.uk)
          1. Institute of Neurology, United Kingdom
            1. Daniel R Weinberger (weinberd{at}intra.nimh.nih.gov)
            1. NIMH, United States
              1. John Rothwell (j.rothwell{at}ion.ucl.ac.uk)
              1. Institute of Neurology, United Kingdom
                1. Roger A Barker (rab46{at}cam.ac.uk)
                1. University of Cambridge, United Kingdom
                  1. Kailash P Bhatia (k.bhatia{at}ion.ucl.ac.uk)
                  1. Institute of Neurology, United Kingdom

                    Abstract

                    Levodopa induced dyskinesias (LID) are a common problem which ultimately limit the effective treatment of patients with Parkinson's disease (PD). There is accumulating evidence that LID develop due to abnormal synaptic plasticity which is in turn influenced by the release of Brain Derived Neurotrophic factor (BDNF). In this study we have looked at the influence of a common functional polymorphism of the BDNF gene on the risk of developing dyskinesias in a large cohort of patients with PD (n=315), who were independently and variably treated with levodopa and/or other dopaminergic treatments. We found that patients with the met allele of BDNF, associated with lower activity dependent secretion of BDNF, are at significantly higher risk of developing dyskinesias earlier in the course of treatment with dopaminergic agents (HR for each additional met allele 2.12, p=0.001), which persists following adjustment for potential confounding variables. This suggests that this functional polymorphism may help predict which individuals are most at risk of LID and is consistent with the known actions of BDNF on synaptic plasticity in the striatum.

                    Statistics from Altmetric.com

                    Request permissions

                    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

                    Linked Articles