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Can progressive and non-progressive behavioral variant frontotemporal dementia be distinguished at presentation?
  1. Michael Hornberger
  1. Prince of Wales Medical Research Institute, Australia
    1. Bhaskara P Shelley
    1. Department of Neurology, Father Muller Medical College, India
      1. Christopher M Kipps
      1. Wessex Neurological Centre, Southampton University NHS Trust, Southampton, United Kingdom
        1. Olivier Piguet
        1. Prince of Wales Medical Research Institute, Australia
          1. John R Hodges (j.hodges{at}powmri.edu.au)
          1. Prince of Wales Medical Research Institute, Australia

            Abstract

            Background: Recent findings suggest that behavioral variant frontotemporal dementia (bv-FTD) patients differ in their disease progression (progressive vs. non-progressive patients). The current study investigates whether the two groups can be discriminated by their clinical features at first presentation.

            Methods: Archival clinical data of the Early Onset Dementia Clinic, Cambridge, UK were analyzed of 71 bv-FTD patients: 45 progressive and 26 non-progressive cases with more than 3 years follow-up.

            Results: The subgroups were largely indistinguishable on the basis of the presenting clinical features but could be distinguished on general cognitive (ACE-R) and selected supportive diagnostic features (distractibility, stereotypic speech, impaired activities of daily living (ADLs) and current depression).

            Conclusions: Progressive and non-progressive patients are difficult to differentiate on the basis of current clinical diagnostic criteria for FTD but a combination of general cognitive, executive dysfunction and impaired ADL measures appear to be the most promising discriminators.

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