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A longitudinal diffusion tensor imaging study in symptomatic Huntington’s disease
  1. Anusha Sritharan (anushas{at}bigpond.com)
  1. Monash University, Australia
    1. Gary Egan (gary.egan{at}expertis.com.au)
    1. Howard Florey University, Centre for Neuroscience, University of Melbourne, Australia
      1. Leigh Johnston (leigh.johnston{at}florey.edu.au)
      1. Department of Electrical and Electronic Engineering, University of Melbourne, Parkville, Victoria, Australia
        1. Malcolm Horne
        1. Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
          1. John Bradshaw
          1. School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, Australia
            1. India Bohanna
            1. Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
              1. Hamed Asadi
              1. School of Medicine, University of Melbourne, Parkville, Victoria, Australia
                1. Ross Cunnington
                1. Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
                  1. Andrew Churchyard
                  1. Department of Neurology, Monash Medical Centre, Clayton, Victoria, Australia
                    1. Phyllis Chua
                    1. School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, Australia
                      1. Maree Farrow
                      1. School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, Australia
                        1. Nellie Georgiou-Karistianis (nellie.georgiou-karistianis{at}med.monash.edu.au)
                        1. School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, Australia

                          Abstract

                          Objective: The striatum, and its projections, are thought to be the earliest sites of Huntington’s disease (HD) pathology. This study aimed to investigate progression of striatal pathology in symptomatic HD using diffusion tensor imaging.

                          Method: Diffusion weighted images were acquired in 18 HD patients and 17 healthy controls twice, one year apart. Mean diffusivity (MD) was calculated in the caudate, putamen, thalamus and corpus callosum, and compared between groups. In addition, caudate width was measured using T1 high resolution images and correlated with caudate MD. Correlation analyses were also performed in HD between caudate/putamen MD and clinical measures.

                          Results: MD was significantly higher in caudate and putamen bilaterally for patients, compared to controls, at both time points, although there were no significant MD differences in thalamus or corpus callosum. For both groups, MD did not change significantly in any region from baseline to year one. There was a significant negative correlation between caudate width and MD in patients at baseline but no correlation between these parameters in controls. There was also a significant negative correlation between Mini Mental State Examination scores and caudate MD and putamen MD at both time points in HD.

                          Conclusions: We report that microstructural changes influence the cognitive status in HD. Although MD was significantly higher in HD, compared to controls at both time points, there were no longitudinal changes in either group. This finding does not rule out the possibility that MD could be a sensitive biomarker for detecting early change in preclinical HD.

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