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Magnetic Resonance Evidence of Cerebellar Cortical Pathology in Multiple Sclerosis
  1. Massimiliano Calabrese1,*,
  2. Irene Mattisi1,
  3. Alice Favaretto1,
  4. Francesca Rinaldi1,
  5. Matteo Atzori1,
  6. Valentina Bernardi1,
  7. Luigi Barachino2,
  8. Chiara Romualdi1,
  9. Luciano Rinaldi1,
  10. Paola Perini1,
  11. Paolo Gallo1
  1. 1 Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Italy;
  2. 2 Neuroradiology Unit, Euganea Medica, Padova, Italy
  1. Correspondence to: Massimiliano Calabrese, Dept. of Neurosciences, Multiple Sclerosis Centre of Veneto region, University Hospital of Padova, Via Giustiniani 2, Padova, 35128, Italy; calabresem{at}


Background: Although neuropathological observations suggest that cerebellar cortex is a major site of demyelination in Multiple Sclerosis (MS), only a few magnetic resonance imaging (MR) studies on cerebellar cortical pathology in MS are available.

Objective: To analyze cerebellar cortical volume (CCV) and leukocortical lesions (CL) in MS, and their impact on clinical disability.

Methods: We studied 125 patients divided into 38 CIS, 35 RRMS, 27 SPMS and 25 PPMS, and 32 normal controls (NC). CCV and cerebellar CL number and volume were evaluated by means of Freesurfer software and Double Inversion Recovery, respectively.

Results: Compared to NC (mean 113.2±2.6 cm3), the CCV was significantly reduced in CIS (105.4±2.2 cm3, p=0.018), RRMS (104.0±2.0 cm3, p=0.012), SPMS (98.8±2.0 cm3, p<0.001) and PPMS (100.6±2.2 cm3, p<0.001), even after age, gender and mean cortical volume correction. CL were observed in all patient groups and were an independent predictor of CCV and cerebellar dysfunction.

Discussion: We confirm that the cerebellar cortex is severely and early affected by MS pathology. The monitoring of cerebellar cortical atrophy and CL may help to understand the mechanism underlying disability progression in MS.

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