Article Text

other Versions

PDF
Letter
What's in a name? Neuronal intermediate filament inclusion disease (NIFID), frontotemporal lobar degeneration-intermediate filament (FTLD-IF) or frontotemporal lobar degeneration-fused in sarcoma (FTLD-FUS)?
  1. R Menon1,
  2. A Baborie1,
  3. E Jaros2,
  4. D M A Mann3,
  5. P S Ray1,
  6. A J Larner1
  1. 1Walton Centre for Neurology and Neurosurgery, Liverpool, UK
  2. 2Neuropathology/Cellular Pathology, Royal Victoria Infirmary, and Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
  3. 3Neurodegeneration and Mental Health Research Group, Greater Manchester Neurosciences Centre, University of Manchester, Salford, UK
  1. Correspondence to Dr A J Larner, Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool L9 7LJ, UK; a.larner{at}thewaltoncentre.nhs.uk

Statistics from Altmetric.com

Neuronal intermediate filament inclusion disease (NIFID) is a neurodegenerative disorder of a heterogeneous clinical phenotype, encompassing behavioural changes, language impairment, perseveration, executive dysfunction with or without early onset dementia, extrapyramidal features, and subclinical or clinical involvement of upper and lower motor neurons, with age at onset of reported cases ranging from 23 to 56 years (table 1).1–5 NIFID was initially characterised neuropathologically on the basis of intraneuronal cytoplasmic inclusions of variable morphology which immunostained for all class IV intermediate filament (IF) proteins, namely NF-H, NF-M, NF-L and alpha-internexin.1–3 5 More recently it has been shown that a much larger proportion of the inclusions in NIFID are immunoreactive with the fused in sarcoma (FUS) protein than with IF,6 leading to changes in the suggested nomenclature.7 8 We present a further case demonstrating the broad phenotypic features, overlapping with both corticobasal degeneration and motor neuron disease.

View this table:
Table 1

Approximate frequencies of clinical features in neuronal intermediate filament inclusion disease cases at presentation and follow-up (n=16)1 2 4 5

A 62-year-old right-handed woman presented with a 2-year history of progressive difficulty with coordination and balance. She noticed weak grip and poor coordination in her right hand when playing tennis and had difficulty assembling familiar scuba diving equipment. She developed involuntary twitching of the fingers in the right hand and heaviness in the right arm. Over the next few months asymmetric leg weakness …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.