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Once-weekly risedronate for prevention of hip fracture in women with Parkinson's disease: a randomised controlled trial
  1. Yoshihiro Sato1,
  2. Jun Iwamoto2,
  3. Yoshiaki Honda1
  1. 1Department of Neurology, Mitate Hospital, Tagawa, Japan
  2. 2Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
  1. Correspondence to Dr Yoshihiro Sato, Department of Neurology, Mitate Hospital, 3237 Yugeta, Tagawa 826-0041, Japan; y-sato{at}ktarn.or.jp

Abstract

Background Incidence of a fracture, particularly in the hip joint, is high in Parkinson's disease (PD), owing to the immobilisation-induced bone resorption and vitamin D deficiency with reduced bone mineral density (BMD). The authors previously demonstrated the lowered incidence of hip fractures in PD by daily administration of risedronate and vitamin D.

Methods This randomised, double-blind, placebo-controlled study was conducted to determine the efficacy of 17.5 mg once-weekly risedronate in the prevention of hip fracture in women with PD. Patients were randomly assigned to 17.5 mg risedronate once a week (n=136) or a placebo (n=136) combined with daily 1000 IU of ergocalciferol. Incidence of hip fractures was compared between the two groups during the 2-year follow-up.

Results Hip fractures occurred in 15 patients in the placebo group and 3 patients in the risedronate group. The RR for hip fractures in the risedronate group as compared with the placebo group was 0.20 (95% CI 0.06 to 0.66). In the risedronate group, serum calcium levels decreased during the follow-up, while the levels in the placebo group increased. BMD increased by 3.4% in the risedronate group and decreased by 3.2% in the placebo group (p<0.01).

Conclusions Treatment with once-weekly risedronate and ergocalciferol prevents hip fractures in older women with PD.

  • Hip fracture
  • osteoporosis
  • Parkinson's disease
  • risedronate
  • rehabilitation

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Footnotes

  • Funding This study was partially supported by the Mitate Hospital, Tagawa, Japan.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the local ethics committee of Mitate Hospital.

  • Provenance and peer review Not commissioned; not externally peer reviewed.

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