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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2011-301655
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Cerebral metabolic rate for glucose of NPH patients increases in shunt-reponders

  1. C Anile1
  1. 1Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
  2. 2Department of Nuclear Medicine, Catholic University School of Medicine, Rome, Italy
  1. Correspondence to Dr Pasquale De Bonis, Institute of Neurosurgery, Catholic University School of Medicine, L go F. Vito, 1, Rome 00168, Italy; debonisvox{at}gmail.com
  1. Contributors AM: conception and design, interpretation of data, drafting the article and final approval of the version to be published. MLC: conception and design, analysis and interpretation of data, drafting the article and final approval of the version to be published. PDB: analysis and interpretation of data, drafting the article and revising it critically for important intellectual content, and final approval of the version to be published. LR: drafting the article and final approval of the version to be published. AP: conception and design and final approval of the version to be published. MDLV: analysis and interpretation of data, drafting the article and final approval of the version to be published. LI: analysis and interpretation of data and final approval of the version to be published. AG: revising the article critically for important intellectual content and final approval of the version to be published. CA: conception and design, revising the article critically for important intellectual content and final approval of the version to be published.

  • Received 16 October 2011
  • Revised 16 November 2011
  • Accepted 17 November 2011
  • Published Online First 21 December 2011

Introduction

Normal pressure hydrocephalus (NPH) is a potentially treatable form of dementia characterised by a triad of symptoms (dementia, gait disturbance and urinary incontinence).

This triad is not pathognomic and may also be seen in other degenerative brain diseases (DBD). Diagnosis of NPH is based upon the clinical history/physical examination, brain imaging and CSF dynamics evaluation.1 The regional cerebral metabolic rate for glucose (rCMRglu) has been extensively measured in DBD. However, few PET studies describe a heterogeneous pattern of metabolic alterations in NPH and there is no conclusive evidence at present of an increase in metabolism after insertion of a CSF shunt.2 3

This is a preliminary study reporting changes in PET rCMRglu in patients with NPH …

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