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Research paper
Cognitive and metabolic correlates of emotional vulnerability in patients with temporal lobe epilepsy
  1. Laura Lanteaume1,2,
  2. Eric Guedj3,4,5,
  3. Mireille Bastien-Toniazzo2,
  4. Audrey Magalahaes1,
  5. Olivier Mundler3,4,
  6. Fabrice Bartolomei1,6,7
  1. 1CHU Timone, Service de Neurophysiologie Clinique, Marseille, France
  2. 2Laboratoire Parole et Langage, CNRS UMR 6057, Aix-en-Provence, France
  3. 3APHM, Hôpital de la Timone, Service Central de Biophysique et Médecine Nucléaire, Marseille, France
  4. 4Aix-Marseille Univ, CERIMED, Marseille, France
  5. 5Aix-Marseille Univ, INT, CNRS UMR7289, Marseille, France
  6. 6Université de la Méditerranée, LNN, Marseille, France
  7. 7INSERM, U751, Marseille, France
  1. Correspondence to Dr Laura Lanteaume, Service de Neurophysiologie Clinique, CHU Timone, 264 Rue Saint Pierre, Marseille 13005, France; laura.lanteaume{at}ap-hm.fr

Abstract

Background Recent investigations have suggested that the occurrence of epileptic seizures is not completely random. In particular, various types of psychological changes or life events may act as triggering factors.

Objective To identify a possible link between self-perception of the impact of affective precipitants, cognitive responses modulated by aversive information and brain metabolic modifications in patients with temporal lobe epilepsy (TLE).

Methods The extent to which seizures were elicited or not by emotional precipitants was estimated using a self-reported scale, allowing distinction of two groups: ‘Emo-TLE’ group (patients reporting to have seizures triggered by emotional events) and ‘Other-TLE’ group, which were compared with healthy individuals (‘control’ group). Attentional biases were investigated using the probe detection paradigm, using negative and neutral stimuli. Interictal brain metabolism was studied using FDG-PET, and comparison was made between controls, Emo-TLE and Other-TLE groups.

Results Patients with emotional vulnerability (Emo-TLE) disclosed specific attentional biases towards negative stimuli compared with the Other-TLE and control groups. Patients with Emo-TLE also exhibited specific hypometabolism in the anterior temporal lobe, including amygdala and hippocampus. The degree of attentional biases correlated with decreased metabolism in these regions.

Conclusions This investigation shows that the impact of affective events is the result of self-perception and also that it might be determined by specific cognitive and brain metabolic modifications in TLE.

  • Stress
  • attention
  • limbic system
  • PET/functional imaging
  • epilepsy
  • cognitive electrophysiology
  • neurophysiology
  • PET
  • SPECT
  • nuclear medicine

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Footnotes

  • Funding This study was supported by AP-HM PHRC, 2007/2009.

  • Competing interests None.

  • Patient consent The article does not contain personal medical information about an identifiable living person.

  • Ethics approval Provided by the local ethics committee and conformed to the Declaration of Helsinki on human investigation.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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