Article Text

other Versions

PDF
Review
Relationship between movement disorders and obsessive–compulsive disorder: beyond the obsessive–compulsive–tic phenotype. A systematic review
  1. Lieneke A Fibbe1,
  2. Danielle C Cath2,
  3. Odile A van den Heuvel1,3,
  4. Dick J Veltman1,
  5. Marina A J Tijssen4,
  6. Anton J L M van Balkom1
  1. 1Department of Psychiatry, VU University Medical Centre and GGZinGeest, Amsterdam, The Netherlands
  2. 2Department of Clinical and Health Psychology, Altrecht Outpatient Anxiety Services, Utrecht University, Utrecht, The Netherlands
  3. 3Department of Anatomy and Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands
  4. 4Department of Neurology, University Medical Centre Groningen, Groningen, The Netherlands
  1. Correspondence to Professor A J L M van Balkom, Department of Psychiatry, VU Medical Centre and GGZinGeest, AJ Ernststraat 1187, Amsterdam 1081HL, The Netherlands; t.vanbalkom{at}ggzingeest.nl

Abstract

Background Obsessive–compulsive disorder (OCD) and symptoms (OC symptoms) are associated with tic disorders and share an aetiological relationship. The extent to which OCD/OC symptoms are correlated with other hyperkinetic movement disorders is unclear. The aim of this review was to investigate this co-occurrence and the extent to which OCD/OC symptoms and hyperkinetic movement disorders share a neurobiological basis.

Methods A systematic review was performed, specifically searching for OCD/OC symptom comorbidity in hyperkinetic movement disorders using case control studies, longitudinal studies and family based studies. The literature search was conducted using PubMed and PsycINFO databases.

Results Heterogeneity of measurement instruments to detect OCD diagnosis and OC symptoms decreased comparability between studies. The most convincing evidence for a relationship was found between the choreas (Huntington's disease and Sydenham's chorea) and OCD/OC symptoms. Furthermore, elevated frequencies of OC symptoms were found in small case control series of dystonias. Small family based studies in dystonia subtypes modestly suggest shared familial/genetic relationships between OC symptoms and dystonia.

Conclusion Current data indicate a relationship between OCD/OC symptoms and the choreas. As OCD and the choreas have been associated with dysfunctional frontal–striatal circuits, the observed relationships might converge at the level of dysfunctions of these circuits. However, paucity of longitudinal and family studies hampers strong conclusions on the nature of the relationship.

Implications The relationship between OCD and movement disorders needs further elaboration using larger family based longitudinal studies and sound instruments to characterise OC symptomatology. This could lead to better understanding of the shared pathology between OCD and hyperkinetic movement disorders.

Statistics from Altmetric.com

Footnotes

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.