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Review
Primary progressive multiple sclerosis: progress and challenges
  1. Claire M Rice1,
  2. David Cottrell2,
  3. Alastair Wilkins3,
  4. Neil J Scolding4
  1. 1University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
  2. 2Department of Neurology, North Bristol Trust, Frenchay Hospital, Bristol, UK
  3. 3Department Neurology, University of Bristol, Frenchay Hospital, Bristol, UK
  4. 4Neurology Department, University of Bristol, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
  1. Correspondence to Professor Neil J Scolding, Neurology Department, University of Bristol, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK; n.j.scolding{at}bristol.ac.uk

Abstract

Primary progressive multiple sclerosis (MS) has long been recognised as presenting great difficulties to our management of what is increasingly a treatable neurological disease. Here we review some basic and clinical aspects of primary progressive MS, and describe how the disorder in fact offers powerful insights and opportunities for better understanding multiple sclerosis, and from a practical perspective an invaluable clinical substrate for studying and treating progressive disability in MS. Difficult hurdles remain, however, and these too are reviewed.

  • Multiple Sclerosis

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