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Fasciculation potentials: a diagnsotic biomarker of early ALS?
  1. Andrew Eisen1,
  2. Steve Vucic2,3
  1. 1Division of Neurology, The University of British Columbia, Vancouver, British Columbia, Canada
  2. 2Sydney Medical School Westmead, University of Sydney, Sydney, New South Wales, Australia
  3. 3Neuroscience Research Australia, Sydney, New South Wales, Australia
  1. Correspondence to Dr Andrew Eisen, Division of Neurology, The University of British Columbia, 2862 Highbury Street, Vancouver, BC, Canada V6R 3T6; eisen{at}mail.ubc.ca

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Fasciculation potentials (FPs) are a spontaneous discharge of a motor units, frequently, but not invariably, visible as a muscle contraction.1 There are probably different neural generators involved, from the motor cortex to the distal nerve terminal, which differs depending on the associated neuromuscular disease.2 FPs bear special relevance to amyotrophic lateral sclerosis (ALS), a disease in which FPs are frequently generalised and profuse, associated with muscle cramping, and may even precede the development of lower motor neuron dysfunction. Indeed, absence of clinical and electrophysiologically recorded FPs raises concern about the diagnosis of …

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