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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2012-304549
  • Impact commentaries
  • A MODERN PERSPECTIVE ON SOME OF THE MOST HIGHLY CITED JNNP PAPERS OF ALL TIME

Frontal lobe dementia, motor neuron disease, and clinical and neuropathological criteria

  1. Julie Snowden1,2
  1. 1Manchester Academic Health Sciences Centre, Cerebral Function Unit, Salford Royal NHS Foundation Trust, Salford, UK
  2. 2Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK
  1. Correspondence to Professor D Neary, Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford M6 8HD, UK;  david.neary{at}srft.nhs.uk
  • Received 14 January 2013
  • Accepted 1 February 2013
  • Published Online First 12 March 2013

DEMENTIA OF FRONTAL LOBE TYPE1

Published: 1988;51:353–61

FRONTAL LOBE DEMENTIA AND MOTOR NEURON DISEASE2

Published: 1990;53:23–32

CLINICAL AND NEUROPATHOLOGICAL CRITERIA FOR FRONTO-TEMPORAL DEMENTIA3

Published: 1994;57:416–18

Graphic

David Neary and Julie Snowden reflect on developments in the understanding of frontotemporal dementia and motor neuron disease since their publications two decades ago

At the beginning of the 1980s the establishment view in the English speaking world was that there were two primary causes of dementia: Alzheimer's disease and vascular disease. Pick's disease was an acknowledged pathological entity but considered sufficiently rare to have little clinical relevance for dementia patients presenting to neurology or psychiatry clinics. In any case it could not be distinguished from Alzheimer's disease in life. It was against this prevailing background that I set up our early onset dementia clinic with Julie Snowden as principal neuropsychologist. My early interest in cognitive neurology and dementia had been consolidated during a sabbatical in Boston in 1976, where I acquired an analytical approach to cognitive assessment and saw firsthand the value of the multidisciplinary clinic. In our own clinic, what rapidly became clear was that patients exhibited very different patterns of difficulty. Far from the ‘global impairment of intellect’ that had …

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