J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2013-305150
  • Editorial commentary

Does suppression of VEGF alone lead to clinical recovery in POEMS syndrome?

  1. Kimiyoshi Arimura1,2
  1. 1Okatsu Neurology and Rehabilitation Hospital, 3-95 Masagohonnmachi, Kagoshima, 890067
  2. 2Department of Neurology and Geriatrics, Kagoshima University School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan
  1. Correspondence to Dr Kimiyoshi Arimura, Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medicine, 8351 Sakuragaoka, Kagoshima 9.80852e+006, Japan; ari{at}
  • Received 19 March 2013
  • Revised 20 March 2013
  • Accepted 24 March 2013
  • Published Online First 3 May 2013

POEMS syndrome (Crow-Fukase syndrome) is a multisystem disorder characterised by polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes. Vascular endothelial growth factor (VEGF) is significantly elevated in serum and used as a good biomarker for diagnosis and disease activity.1 VEGF is a potent, multifunctional cytokine that induces angiogenesis and microvascular hyperpermeability. In POEMS syndrome, VEGF is mainly produced by plasma cells in bone lesions and lymph nodes. In the circulation, excess VEGF is mainly stored in platelets and released during platelet aggregation leading to markedly increased local VEGF concentration. …

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